The NFL’s schedule release is Thursday night, but that isn’t going to stop us from tracking all the rumors (and confirming some where we can). We know the Buffalo Bills play on Monday night in Week 2, but the rest is still a bit mysterious.
Below, you’ll find the Home and Away opponents, plus each week will be listed out along with information relevant to the Bills ’potential opponent and rumors. The table at the bottom is only for confirmed games from a source we trust.
Let’s get after it!
Bills’ 2022 Opponents
Home Games
Away Games
Week-by-week Info
Week 1
– We are reporting by sources that this game is “most likely” to be the Bills vs Los Angeles Rams on the NFL’s Opening Night broadcast, Thursday, September 8th.
– Not the Lions, per Philadelphia Inquirer
– Dolphins at Bills, by Dov Kleiman
Week 2 – OFFICIALLY ANNOUNCED
– Monday, Sept 19, 7:15 PM Eastern vs. Tennessee Titans (Full Story)
Week 3
Week 4
– Not the Packers (via The Athletic, Boston Herald)
– Not the Patriots (via The Athletic, Boston Herald)
– Officially not the Chiefs (vs. TB)
Week 5
– Officially not the Packers (vs. NYG)
– Not the Patriots (by NBC Boston, Boston Herald)
– Not the Lions (by NBC Boston, Boston Herald)
– Not the Chiefs (via 670 Radio Chicago)
Week 6
– Not the Packers (via The Athletic)
– Not the Jets (via The Athletic)
– Not the Bears (via 670 Chicago radio)
– Bills vs Chiefs (via 670 Radio Chicago)
Week 7
– Not the Patriots (per NBC Boston and 670 Radio Chicago and Boston Herald)
– Not the Bears (per NBC Boston and 670 Radio Chicago and Boston Herald)
Week 8
– Not the Bears (via 670 Radio Chicago)
Week 9
– Not the Bears (via 670 Radio Chicago)
Week 10
– Officially not the Packers (vs. DAL)
Week 11
– Not the Packers (via The Athletic)
Week 12
– Persistent but unconfirmed rumors have the Bills on Thanksgiving against the Baltimore Ravens or Detroit Lions.
Week 13
– Bills at Dolphins, by Dov Kleiman
Week 14
– Not the Chiefs (via 670 Radio Chicago)
Week 15
– Not the Packers (via The Athletic)
– Not the Rams (via The Athletic)
Week 16
– Officially not the Rams (vs. DEN)
– Not the Packers (via The Athletic)
– Not the Dolphins (via The Athletic)
Week 17
– Not the Packers (via The Athletic)
– Not the Vikings (via The Athletic)
Week 18
– Typically an AFC East opponent
– Not the Packers (via The Athletic)
– Not the Lions (via The Athletic)
What we know for sure
2022 Buffalo Bills schedule
| Week | Day | Date | Time | Opponent | Notes |
|---|---|---|---|---|---|
| Week | Day | Date | Time | Opponent | Notes |
| Pre-1 | |||||
| Pre-2 | |||||
| Pre-3 | |||||
| 1 | Sep 8 | Sources have indicated this is likely the Thursday night season opener against Rams | |||
| 2 | Monday | Sept 19 | 7:15 ET | TENNESSEE TITANS | Fifth straight season playing Tennessee, but first time in Buffalo since 2018 |
| 3 | Sept 25-26 | ||||
| 4 | Oct 2-3 | ||||
| 5 | Oct 6-10 | ||||
| 6 | Oct 13-17 | @ Kansas City Chiefs | |||
| 7 | Oct 20-24 | ||||
| 8 | Oct 27-31 | ||||
| 9 | Nov 3-7 | ||||
| 10 | Nov 10-14 | ||||
| 11 | Nov 17-21 | ||||
| 12 | Thursday | Nov 24-28 | 12:30 ET | @ Detroit Lions | Played on Thanksgiving 3 of last 4 seasons |
| 13 | Dec 1-5 | ||||
| 14 | Dec 8-12 | ||||
| 15 | Dec 17/18 | ||||
| 16 | Dec 24 | ||||
| 17 | Jan 2 | ||||
| 18 | Jan 7-8 | ||||
| WC | TBD | TBD | TBD | TBD | |
| Div | TBD | TBD | TBD | TBD | |
| AFC | TBD | TBD | TBD | TBD | |
| SB | Sunday | Feb 12 | 6:30 PM | TBD |